Research Scientist – Drug Discovery, Bioinformatics, CADD
- Location
- Across United States
- Salary
- Not specified
- Company
- Akash pawar
Job description
• Role & Company / Project Overview Bachwell Pharma is seeking candidates for two (2) vacancies for the position of Research Scientist specializing in Drug Discovery, Bioinformatics, Computer-Aided Drug Design (CADD), and Molecular Dynamics (MD) simulations. This position supports a US-based incorporation and is targeted towards Ph.D. scholars or senior computational scientists. • Key Responsibilities & Daily Duties 1. Computer-Aided Drug Design (CADD) & Molecular Modeling: - Drive structure-based and ligand-based drug design projects from target identification through lead optimization. - Execute virtual screening, molecular docking, pharmacophore modeling, and Quantitative Structure-Activity Relationship (QSAR) studies to identify and prioritize novel hit compounds. - Collaborate with medicinal chemistry teams to propose structural modifications for improving binding affinity, selectivity, and pharmacokinetic profiles. 2. Molecular Dynamics (MD) Simulations: - Design, execute, and analyze advanced MD simulations (e.g., protein-ligand stability, conformational sampling, free energy perturbation/FEP, and binding free energy calculations) to understand molecular mechanisms at an atomistic level. - Interpret simulation trajectories to rationalize experimental assay results and guide rational drug design strategies. - Optimize computational protocols and leverage high-performance computing (HPC) infrastructure for efficient simulation workflows. 3. Bioinformatics & Target Validation: - Analyze large-scale genomic, proteomic, and structural bioinformatics datasets to identify, validate, and prioritize novel drug targets. - Perform sequence alignment, homology modeling, structural bioinformatics, and functional annotation of target proteins. - Integrate multi-omics data with computational chemistry pipelines to support translational research and mechanism-of-action studies. 4. Cross-Functional Collaboration & Project Leadership: - Partner closely with biology, medicinal chemistry, and pharmacology teams to align computational predictions with experimental validation. - Translate complex computational findings into clear, actionable insights for experimentalists and project stakeholders. - Mentor junior researchers, Ph.D. interns, and research associates in bioinformatics and computational modeling workflows. 5. Documentation & IP Generation: - Maintain rigorous documentation of computational protocols, analysis pipelines, and project results in electronic lab notebooks (ELNs). - Contribute significantly to research publications, conference presentations, and patent filings for novel therapeutic assets. • Required Qualifications, Skills & Experience - Educational Qualifications: Ph.D., M.Sc., or M.Tech (Organic Chemistry / Computational Chemistry / Bioinformatics or related field). - Experience: Ph.D. scholar or 2 to 5 years of experience as a senior computational scientist. - In-depth proficiency in CADD, molecular modeling, MD simulation workflows, HPC environments, and structural bioinformatics tools. • Working Hours, Shifts & Location Details - Location: Remote (for a US-based incorporation). • Application Instructions - Interested candidates should submit their updated profile to the designated recruitment emails.